{"id":11822,"date":"2025-05-30T11:53:48","date_gmt":"2025-05-30T02:53:48","guid":{"rendered":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?page_id=11822"},"modified":"2025-05-30T11:53:48","modified_gmt":"2025-05-30T02:53:48","slug":"3ded-microed","status":"publish","type":"page","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/technology\/drug\/3ded-microed\/","title":{"rendered":"3D ED \/ MicroED crystal structure analysis"},"content":{"rendered":"<p>At SPERA PHARMA, we have added the latest 3D ED\/MicroED (Three-Dimensional Electron Diffraction\/Microcrystal Electron Diffraction) to our conventional X-ray analysis lineup, paving the way for a new chapter in crystal structure analysis.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"color: #000080\"><strong>Features of 3D ED\/MicroED Structural Analysis<\/strong><\/p>\n<ul>\n<li>\u25c6 Capable of analyzing extremely small crystals (under 1\u03bcm) that are difficult to analyze using conventional single-crystal X-ray diffraction equipment.<\/li>\n<li>\u25c6 Analysis of crystalline powder is capable.<\/li>\n<li>\u25c6 Determination of each crystal structure in mixtures is capable.<\/li>\n<\/ul>\n<p style=\"color: #000080\"><strong>Analysis Utilizing the Features of 3D ED\/Micro ED<\/strong><\/p>\n<p><strong>\u30103D-Molecular Structure Analysis\u3011<\/strong><\/p>\n<ul>\n<li>\u25c6 Capable of structural analysis of compounds that are difficult to obtain in sufficient quantities or difficult to prepare single-crystal, such as natural products.<\/li>\n<li>\u25c6 Capable of analyzing mixtures, allowing for the structural analysis of each component even in a crude product before purification.<\/li>\n<li>\u25c6 Allows the determination of absolute configuration clearer than conventional single-crystal X-ray diffraction.<\/li>\n<\/ul>\n<p><strong>\u3010Crystal Structure Analysis\u3011<\/strong><\/p>\n<ul>\n<li>\u25c6 By adding 3D ED\/MicroED analysis data to powder X-ray diffraction (PXRD) charts which have been pattern recognized only, it becomes possible to distinguish crystal polymorphs with crystallographic evidence. This also helps in understanding and identifying pseudo-polymorphic situations.<\/li>\n<li>\u25c6 Enables crystal structure analysis of compounds that are difficult to obtain single crystals that can be analyzed by X-ray crystallography, facilitating the determination of the crystal structure of development compounds in pharmaceutical, agrochemical, or chemical companies.<\/li>\n<li>\u25c6 Capable of analyzing mixtures, allowing application to the preparation process of salts and co-crystals.<\/li>\n<li>\u25c6 Capable of discriminating salt or cocrystal clearer than conventional single-crystal X-ray diffraction, because of the high sensitivity of hydrogen atom.<\/li>\n<\/ul>\n<p style=\"color: #000080\"><strong>Potential Applications of 3D ED\/MicroE<\/strong><\/p>\n<ul>\n<li>\u25c6 Facilitates structure determination even for trace impurities, contributing to pharmaceutical process development.<\/li>\n<li>\u25c6 Accelerates ADMET\/metabolite research by enabling easier structural determination of trace metabolites.<\/li>\n<li>\u25c6 Contributes to the generation of initial structures in computational chemistry by accelerating 3D molecular structure analysis.<\/li>\n<li>\u25c6 By conducting synthetic experiments in parallel, it enables rapid structural determination of intermediates, especially enhancing research efficiency for synthesizing complex compounds.<\/li>\n<li>\u25c6 By measuring the fine powder obtained by grinding, it can contribute to the mechanochemistry field.<\/li>\n<li>\u25c6 By analyzing the ground tablets, the crystal form and molecular structure in the tablets can be confirmed.<\/li>\n<li>\u25c6 Molecular structures can be easily determined even in mixtures, accelerating Diversity-oriented synthesis and contributing to drug discovery by expanding the chemical space.<\/li>\n<li>\u25c6 The structure of the organometallic complex can be easily determined, accelerating catalyst design and reaction development and contributing to process chemistry. <\/li>\n<\/ul>\n<p style=\"color: #000080\"><strong>Example of 3D ED\/Micro ED analysis<\/strong><\/p>\n<ul>\n<li>\u3000Selexipag (Uptravi<sup>\u00ae<\/sup>)<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10366\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1.png\" alt=\"\" width=\"303\" height=\"114\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1.png 417w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1-300x113.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1-240x90.png 240w\" sizes=\"(max-width: 303px) 100vw, 303px\" \/><br \/>\n<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10369\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1.png\" alt=\"\" width=\"699\" height=\"378\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1.png 886w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-300x162.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-768x415.png 768w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-240x130.png 240w\" sizes=\"(max-width: 699px) 100vw, 699px\" \/><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10378\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1.png\" alt=\"\" width=\"703\" height=\"251\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1.png 972w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-300x107.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-768x274.png 768w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-240x86.png 240w\" sizes=\"(max-width: 703px) 100vw, 703px\" \/><\/p>\n<p><strong>SPERA PHARMA not only offers 3D ED\/MicroED structural analysis services as part of its lineup but also provides strong support for our customer\u2019s research and development from various angles.<\/strong><\/p>\n<style>\n.child-contents ul {\n  list-style: none;\n  margin-left: 1.75em;\n  text-indent: -1.25em;\n}\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>At SPERA PHARMA, we have added the latest 3D ED\/MicroED (Three-Dimensional Electron Diffraction\/Microcrystal E [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2327,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?page_id=11816","footnotes":""},"class_list":["post-11822","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/11822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=11822"}],"version-history":[{"count":1,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/11822\/revisions"}],"predecessor-version":[{"id":11823,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/11822\/revisions\/11823"}],"up":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2327"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=11822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}