{"id":2410,"date":"2018-12-15T21:44:09","date_gmt":"2018-12-15T12:44:09","guid":{"rendered":"http:\/\/spera.rdy.jp\/?page_id=2410"},"modified":"2019-02-20T03:26:59","modified_gmt":"2019-02-19T18:26:59","slug":"support-for-drug-discovery","status":"publish","type":"page","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/technology\/drug\/support-for-drug-discovery\/","title":{"rendered":"Support for drug discovery"},"content":{"rendered":"<p>New synthetic methodologies found during API process R&#038;D are also able to support drug discovery activities.<\/p>\n<p>For example, we have developed convenient and diversified synthetic methods for pharmacore of drug candidates (e.g. heterocycle), and a reliable functional group transformation method, etc. The synthetic methods can contribute to accelerating drug discovery research timeline, providing large amount of the key intermediates of medicinal chemistry.<\/p>\n<table class=\"table\">\n<tr>\n<th>Examples of synthesis<\/th>\n<th>paper\u00b7oral presentation<\/th>\n<\/tr>\n<tr>\n<td>Synthetic reagent for quinolines (Novel vinamidinium salt)<\/td>\n<td>Tetrahedron, <strong>2014<\/strong>, 70, 2370<\/td>\n<\/tr>\n<tr>\n<td>Synthetic method for cores of kinase inhibitors (\u03b1-carboline)<\/td>\n<td>Tetrahedron, <strong>2014<\/strong>, 70, 5550<br \/>J. Org. Chem, <strong>2015<\/strong>, 80, 1564<br \/>Tetrahedron, <strong>2017<\/strong>, 73, 5946<br \/>Interphex Japan (2014)<\/td>\n<\/tr>\n<tr>\n<td>Synthetic method for pyrazoles<\/td>\n<td>Tetrahedron, <strong>2015<\/strong>, 71, 2833<br \/>Interphex Japan (2016)<\/td>\n<\/tr>\n<tr>\n<td>Synthetic method for naphthalenes (Analogues of lignan type natural products)<\/td>\n<td>Tetrahedron, <strong>2006<\/strong>, 62, 8539<br \/>Outlook of support research for drug discovery (CMC Publishing, 2008)<\/td>\n<\/tr>\n<tr>\n<td>Conversion of phenol to aniline (effective Smiles rearrangement)<\/td>\n<td>Org. Lett. <strong>2005<\/strong>, 7, 3629<br \/>Organic Syntheses, <strong>2007<\/strong>, 84, 325<\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>New synthetic methodologies found during API process R&#038;D are also able to support drug discovery activiti [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2327,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"694","footnotes":""},"class_list":["post-2410","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=2410"}],"version-history":[{"count":0,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2410\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2327"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=2410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}