{"id":2426,"date":"2018-12-15T21:54:00","date_gmt":"2018-12-15T12:54:00","guid":{"rendered":"http:\/\/spera.rdy.jp\/?page_id=2426"},"modified":"2019-02-20T03:32:40","modified_gmt":"2019-02-19T18:32:40","slug":"release-controlled-granules","status":"publish","type":"page","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/technology\/formulation\/release-controlled-granules\/","title":{"rendered":"Modified and sustained release technologies (Dual delayed release granules)"},"content":{"rendered":"<h4>Two kinds of granules coated with different polymers which is melt in specific pH enable dual release of API<\/h4>\n<div class=\"img\">\n\t<a href=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"437\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en.jpg\" alt=\"Two kinds of granules coated with different polymers which is melt in specific pH enable dual release of API\" class=\"alignnone size-full wp-image-4221\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en.jpg 850w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en-300x154.jpg 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en-768x395.jpg 768w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation01en-240x123.jpg 240w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><\/a>\n<\/div>\n<p>By combining two types of Immediate release (IR) and Delayed release (DR) enteric pellets, a longer e\ufb00ective blood plasma<br \/>\nconcentration for clinical purposes was achieved.<\/p>\n<h4>API release from granules is controlled slow in acidic to accelerate in neutral<\/h4>\n<div class=\"img\">\n\t<a href=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation02en.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"756\" height=\"557\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation02en.jpg\" alt=\"API release from granules is controlled slow in acidic to accelerate in neutral\" class=\"alignnone size-full wp-image-4222\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation02en.jpg 756w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation02en-300x221.jpg 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation02en-217x160.jpg 217w\" sizes=\"(max-width: 756px) 100vw, 756px\" \/><\/a>\n<\/div>\n<p>This technology is applied to treatment of morphine-based long-acting cancer pain (capsule formulation) which is currently marketed in Japan, and has earned a high reputation from clinical sites.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Two kinds of granules coated with different polymers which is melt in specific pH enable dual release of API B [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2366,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"767","footnotes":""},"class_list":["post-2426","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=2426"}],"version-history":[{"count":1,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2426\/revisions"}],"predecessor-version":[{"id":4223,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2426\/revisions\/4223"}],"up":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2366"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=2426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}