{"id":4239,"date":"2019-02-03T22:29:38","date_gmt":"2019-02-03T13:29:38","guid":{"rendered":"http:\/\/spera.rdy.jp\/?page_id=4239"},"modified":"2019-02-20T03:49:19","modified_gmt":"2019-02-19T18:49:19","slug":"direct-particle-coating-formulation","status":"publish","type":"page","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/technology\/formulation\/direct-particle-coating-formulation\/","title":{"rendered":"Direct particle coating technology"},"content":{"rendered":"<h4>Direct particle coating formulation to mask disadvantageous API properties to add some value on formulation<\/h4>\n<h5>Background<\/h5>\n<p>API physical properties often become key restrictions to make solid formulation. For the wet particle coating process, direct particulate coating has the following advantages.<\/p>\n<ul>\n<li>Low manufacturing cost<\/li>\n<li>Stabilization of drug product for water \/ heat-sensitive API<\/li>\n<li>High drug loading formulation \/ Downsizing tablets<\/li>\n<li>Odor \/ Taste masking<\/li>\n<\/ul>\n<h5>Direct particle coating technology<\/h5>\n<p>In the dry condition without solvent, by addition of large energy as such impact or share force, small particles cover the surface of a large particle (Ordered mixture). By further addition of the force, small particles fuse on the large particle (Mechanofusion).<\/p>\n<div class=\"img\">\n\t<a href=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation08en.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"402\" height=\"390\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation08en.jpg\" alt=\"Mechanism of dry powder composition system\" class=\"alignnone size-full wp-image-4240\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation08en.jpg 402w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation08en-300x291.jpg 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2019\/02\/formulation08en-165x160.jpg 165w\" sizes=\"(max-width: 402px) 100vw, 402px\" \/><\/a>\n<\/div>\n<p>Formulation using this technology was successfully developed, and applied to clinical trial materials of a compound in development stage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Direct particle coating formulation to mask disadvantageous API properties to add some value on formulation Ba [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2366,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"3988","footnotes":""},"class_list":["post-4239","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/4239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=4239"}],"version-history":[{"count":0,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/4239\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/pages\/2366"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=4239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}