{"id":11060,"date":"2024-11-07T11:09:57","date_gmt":"2024-11-07T02:09:57","guid":{"rendered":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?p=11060"},"modified":"2024-11-12T08:26:31","modified_gmt":"2024-11-11T23:26:31","slug":"2024%e5%b9%b44%e6%9c%88-microed%e7%b5%90%e6%99%b6%e6%a7%8b%e9%80%a0%e8%a7%a3%e6%9e%90%e3%81%ae%e5%8f%97%e8%a8%97%e3%82%92%e5%a7%8b%e5%8b%95%ef%bc%81","status":"publish","type":"post","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/pick-up\/p11060\/","title":{"rendered":"From April 2024, 3D ED\/MicroED crystal structure analysis contracting begins!"},"content":{"rendered":"<p>At SPERA PHARMA, we have added the latest 3D ED\/MicroED (Three-Dimensional Electron Diffraction\/Microcrystal Electron Diffraction) to our conventional X-ray analysis lineup, paving the way for a new chapter in crystal structure analysis.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080\"><strong>Features of 3D ED\/MicroED Structural Analysis<\/strong><\/span><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>\u25c6 Capable of analyzing extremely small crystals (under 1\u03bcm) that are difficult to analyze using conventional single-crystal X-ray diffraction equipment.<\/li>\n<li>\u25c6 Analysis of crystalline powder is capable.<\/li>\n<li>\u25c6 Determination of each crystal structure in mixtures is capable.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080\"><strong>Analysis Utilizing the Features of 3D ED\/Micro ED<\/strong><\/span><\/p>\n<p><strong>\u30103D-Molecular Structure Analysis\u3011<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>\u25c6 Capable of structural analysis of compounds that are difficult to obtain in sufficient quantities or difficult to prepare single-crystal, such as natural products.<\/li>\n<li>\u25c6 Capable of analyzing mixtures, allowing for the structural analysis of each component even in a crude product before purification.<\/li>\n<li>\u25c6 Allows the determination of absolute configuration clearer than conventional single-crystal X-ray diffraction.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>\u3010Crystal Structure Analysis\u3011<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>\u25c6 By adding 3D ED\/MicroED analysis data to powder X-ray diffraction (PXRD) charts which have been pattern recognized only, it becomes possible to distinguish crystal polymorphs with crystallographic evidence. This also helps in understanding and identifying pseudo-polymorphic situations.<\/li>\n<li>\u25c6 Enables crystal structure analysis of compounds that are difficult to obtain single crystals that can be analyzed by X-ray crystallography, facilitating the determination of the crystal structure of development compounds in pharmaceutical, agrochemical, or chemical companies.<br \/>\n\u25c6 Capable of analyzing mixtures, allowing application to the preparation process of salts and co-crystals.<br \/>\n\u25c6 Capable of discriminating salt or cocrystal clearer than conventional single-crystal X-ray diffraction, because of the high sensitivity of hydrogen atom.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"color: #000080\"><strong>Potential Applications of 3D ED\/MicroED\u00a0<\/strong><\/span><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>\u25c6 Facilitates structure determination even for trace impurities, contributing to pharmaceutical process development.<br \/>\n\u25c6 Accelerates ADMET\/metabolite research by enabling easier structural determination of trace metabolites.<\/li>\n<li>\u25c6 Contributes to the generation of initial structures in computational chemistry by accelerating 3D molecular structure analysis.<\/li>\n<li>\u25c6 By conducting synthetic experiments in parallel, it enables rapid structural determination of intermediates, especially enhancing research efficiency for synthesizing complex compounds.<\/li>\n<li>\u25c6 By measuring the fine powder obtained by grinding, it can contribute to the mechanochemistry field.<\/li>\n<li>\u25c6 By analyzing the ground tablets, the crystal form and molecular structure in the tablets can be confirmed.<\/li>\n<li>\u25c6 Molecular structures can be easily determined even in mixtures, accelerating Diversity-oriented synthesis and contributing to drug discovery by expanding the chemical space.<\/li>\n<li>\u25c6 The structure of the organometallic complex can be easily determined, accelerating catalyst design and reaction development and contributing to process chemistry.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080\"><strong>Example of 3D ED\/Micro ED analysis<\/strong><\/span><\/p>\n<ul>\n<li>\u00a0Selexipag (Uptravi<sup>\u00ae<\/sup>)<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10366\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1.png\" alt=\"\" width=\"303\" height=\"114\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1.png 417w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1-300x113.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/f0004d8c72dfc8e016b217d4fd18b8b1-240x90.png 240w\" sizes=\"(max-width: 303px) 100vw, 303px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10369\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1.png\" alt=\"\" width=\"699\" height=\"378\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1.png 886w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-300x162.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-768x415.png 768w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/41824c39077aa52ad333e702206649f1-240x130.png 240w\" sizes=\"(max-width: 699px) 100vw, 699px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10378\" src=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1.png\" alt=\"\" width=\"703\" height=\"251\" srcset=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1.png 972w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-300x107.png 300w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-768x274.png 768w, https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-content\/uploads\/2024\/03\/6e08656dcd0450112d2e4893bd28d7c4-1-240x86.png 240w\" sizes=\"(max-width: 703px) 100vw, 703px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>For inquiries regarding this service, please click the button below.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/inquiry\/\" class=\"su-button su-button-style-default\" style=\"color:#FFFFFF;background-color:#2D89EF;border-color:#246ec0;border-radius:5px\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color:#FFFFFF;padding:0px 16px;font-size:13px;line-height:26px;border-color:#6cadf4;border-radius:5px;text-shadow:none\"> Inquiry<\/span><\/a>\n<p>&nbsp;<\/p>\n<p>SPERA PHARMA not only offers 3D ED\/MicroED structural analysis services as part of its lineup but also provides strong support for our customer\u2019s research and development from various angles.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At SPERA PHARMA, we have added the latest 3D ED\/MicroED (Three-Dimensional Electron Diffraction\/Microcrystal E [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":10390,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?p=10364","footnotes":""},"categories":[4,6],"tags":[71,84,74],"class_list":["post-11060","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pick-up","category-news","tag-71","tag-3d-ed","tag-microed","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/11060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=11060"}],"version-history":[{"count":7,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/11060\/revisions"}],"predecessor-version":[{"id":11178,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/11060\/revisions\/11178"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media\/10390"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=11060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/categories?post=11060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/tags?post=11060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}