{"id":12994,"date":"2026-03-02T15:07:19","date_gmt":"2026-03-02T06:07:19","guid":{"rendered":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?p=12994"},"modified":"2026-03-02T15:07:19","modified_gmt":"2026-03-02T06:07:19","slug":"research-achievement-research-result-on-a-novel-221-radical-annulation-reaction-enabled-by-3d-ed-microed-have-been-published-joint-research-with-meiji-pharmaceutical-university","status":"publish","type":"post","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/pick-up\/p12994\/","title":{"rendered":"[Research Achievement] Research result on a novel [2+2+1] radical annulation reaction enabled by 3D ED\/MicroED have been published (Joint Research with Meiji Pharmaceutical University)"},"content":{"rendered":"

A co-authored research paper by Keiyo Nakai and Mitsuhisa Yamano (SPERA PHARMA), together with Professor Nozomi Saito and Professor Masanori Tayu of Meiji Pharmaceutical University, has been published in The Journal of Organic Chemistry.<\/p>\n

 <\/p>\n

Journal: \u3000The Journal of Organic Chemistry<\/strong><\/span><\/p>\n

Title: \u3000\u00a0 \u00a0 \u00a0 \u00a0De Novo Synthesis of Multisubstituted Pyrrolidines <\/strong><\/span>
\n\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Based on a Programmed Radical [2 + 2 + 1] Annulation Strategy <\/strong><\/span>
\n \u3000\u3000\u3000\u00a0 \u3000\u00a0 \u00a0 Using Sulfide-Based Electron Donor\u2212Acceptor Catalysis<\/strong><\/span><\/p>\n

URL:<\/strong> \u3000\u3000\u00a0 \u00a0\u00a0https:\/\/doi.org\/10.1021\/acs.joc.5c02978<\/a><\/span><\/p>\n

Authors:\u00a0 \u00a0 \u00a0 Kakeru Matsukuma, Masanori Tayu,* Keiyo Nakai, Mitsuhisa Yamano, <\/strong><\/span><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/sup>Sayaka Ohrui, Tomohisa Yamaguchi, and Nozomi Saito*<\/strong><\/span><\/p>\n

 <\/p>\n

In this study, we report a highly selective and novel [2+2+1] radical annulation reaction between a specific N\u2011hydroxyphthalimide (NHPI) ester and two electronically tuned alkenes, which constitutes the central theme of the work. The structures of the key products obtained were determined using 3D ED\/MicroED crystal structure analysis, a technique in which our company has particular expertise.<\/p>\n

This achievement has been highly recognized as a significant advancement in the field of synthetic chemistry and was selected for the journal\u2019s Front Cover. Co-author Keiyo Nakai of our Chemical R&D Laboratory commented, \u201cIn the structural determination of small-molecule compounds, 3D ED\/MicroED is an exceptionally powerful technique that can deliver results with remarkable speed. I believe this method should become increasingly widespread in synthetic chemistry research.\u201d<\/p>\n

 <\/p>\n

SPERA PHARMA will continue to leverage the technologies and expertise it has cultivated over the years to provide strong support in addressing our customers\u2019 challenges.
\nFor inquiries regarding MicroED-based structural analysis, please feel free to contact us using the button below.<\/p>\n

 <\/p>\n

Inquiry<\/span><\/a>\n","protected":false},"excerpt":{"rendered":"

A co-authored research paper by Keiyo Nakai and Mitsuhisa Yamano (SPERA PHARMA), together with Professor Nozom […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?p=12984","footnotes":""},"categories":[4,6],"tags":[99,84,74,85],"class_list":["post-12994","post","type-post","status-publish","format-standard","hentry","category-pick-up","category-news","tag-99","tag-3d-ed","tag-microed","tag-spera-pharma","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/12994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=12994"}],"version-history":[{"count":9,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/12994\/revisions"}],"predecessor-version":[{"id":13018,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/12994\/revisions\/13018"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=12994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/categories?post=12994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/tags?post=12994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}