{"id":7628,"date":"2021-02-18T15:58:14","date_gmt":"2021-02-18T06:58:14","guid":{"rendered":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/?p=7628"},"modified":"2022-04-05T23:09:22","modified_gmt":"2022-04-05T14:09:22","slug":"%e3%80%90research-achievements%e3%80%91a-paper-was-published-in-tetrahedron-letters","status":"publish","type":"post","link":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/en\/news\/p7628\/","title":{"rendered":"\u3010Research Achievements\u3011A paper was published in Tetrahedron Letters"},"content":{"rendered":"<p><span lang=\"EN-US\">A paper by Masatoshi Yamada and others of the Pharmaceutical Research Division has been published in the academic journal &#8220;Organic Process Research &amp; Development&#8221; of the American Chemical Society.<\/span><\/p>\n<p>\u3010Details of the paper\u3011<\/p>\n<p>Journal: Organic Process Research\uff06Development<\/p>\n<p>Title: Rhodium-Catalyzed Highly Enantioselective Hydrogenation of a Tetrasubstituted Enamine<\/p>\n<p>Publication date: March 1, 2021<\/p>\n<p>Authors: Masatoshi Yamada*, Tomoaki Kato, Tomomi Ikemoto, and Mitsuhisa Yamano<\/p>\n<p>URL\uff1a<a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.oprd.1c00007\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.oprd.1c00007<\/a><\/p>\n<p>DOI\uff1a<a href=\"https:\/\/doi.org\/10.1021\/acs.oprd.1c00007\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1021\/acs.oprd.1c00007<\/a><\/p>\n<p>Summary: A paper was published on the asymmetric hydrogenation of tetra-substituted enamines, which was developed as a new synthetic method for developmental compounds during the Takeda era. Hydrogenation of tetra-substituted enamines, which generally undergo stereoselective reactions with difficulty, was successfully achieved with high enantioselectivity and high conversion rate.<\/p>\n<p>A highly efficient catalytic reaction was achieved with a catalytically active species that was presumed to be produced by a combination of an original ruthenium metal catalyst and a weak base, such as potassium carbonate.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A paper by Masatoshi Yamada and others of the Pharmaceutical Research Division has been published in the acade [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"7626","footnotes":""},"categories":[6],"tags":[],"class_list":["post-7628","post","type-post","status-publish","format-standard","hentry","category-news","en-US"],"acf":[],"_links":{"self":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/7628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/comments?post=7628"}],"version-history":[{"count":3,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/7628\/revisions"}],"predecessor-version":[{"id":7631,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/posts\/7628\/revisions\/7631"}],"wp:attachment":[{"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/media?parent=7628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/categories?post=7628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/heuristic-ardinghelli.153-122-123-210.plesk.page\/wp-json\/wp\/v2\/tags?post=7628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}